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Case Report
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| Treat secondary amenorrhea by oophorectomy: A case of adult granulosa cell tumor with pseudo-FSH deficiency manifested by secondary amenorrhea | ||||||
| Hoo PS1, Nik Rafiza Afendi2, Lou Wei Yeng3, Ahmad Shuib Yahaya3, Ahmad Amir Ismail2, Rahimah Abdul Rahim2, Ahmad Akram Omar2, Mohd Pazudin Ismail4 | ||||||
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1Clinical Lecturer, Obstetrics & Gynecology department, School of Medical Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
2Senior Lecturer, Obstetrics & Gynecology Department, School of Medical Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia. 3Trainee Registrar, Obstetrics & Gynecology department, School of Medical Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia; Lecturer, Faculty of Medicine & health Sciences Universiti Putra Malaysia. 4Senior Lecturer/consultant, Head of Obstetrics & Gynecology Department, School of Medical Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia. | ||||||
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| Hoo PS, Afendi NR, Yeng LW, Yahaya AS, Ismail AA, Rahim RA, Omar AA, Ismail MP. Treat secondary amenorrhea by oophorectomy: A case of adult granulosa cell tumor with pseudo-FSH deficiency manifested by secondary amenorrhea. Edorium J Gynecol Obstet 2017;3:1–4. |
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Abstract
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Introduction:
Granulosa cell tumor of the ovary is a very rare cancer, accounting for only 0.6–3% of all ovarian tumors. Histologically, it belongs to the category of sex-cord stromal tumors, comprising 70% of tumors of this group. Commonly, the tumors secrete oestrogen, so the patients usually presented with precocious puberty, menorrhagia, metrorrhagia or post-menopausal bleed.
Case Report: We report a case of adult granulosa cell tumor of right ovary with atypical presentation. The patient presented to us with secondary amenorrhea. Ultrasound scan showed mixed solid cystic right adnexal mass measuring 6.7x9.5x8.7 cm. The preoperative hormonal profiles showed suppressed follicle stimulating hormone (FSH) 0.2 IU/L, normal luteinizing hormone 8.1 IU/L, elevated estradiol 650.1 pmol/L and testosterone 2.5 nmol/L but no sign of virilization. Laparotomy salpingo-oophorectomy and omentectomy was electively performed and she regains her menses and her hormonal profiles were normalized one month later. The histopathology reported as adult granulosa cell tumor stage 1A. She is still under our outpatient follow-up. Conclusion: Sudden onset of secondary amenorrhea with ovarian tumor should raise high suspicion of hormonal secreting tumor. | |
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Keywords:
Granulosa cell tumor, Secondary amenorrhea, Sex-cord stromal tumor
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Author Contributions
Hoo PS – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published. Nik Rafiza Afendi – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Lou Wei Yeng – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Ahmad Shuib Yahaya – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Ahmad Amir Ismail – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published. Rahimah Abdul Rahim – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Final approval of the version to be published. Ahmad Akram Omar – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Final approval of the version to be published. Mohd Pazudin Ismail – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Final approval of the version to be published. |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2017 Hoo PS et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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