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Original Article
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| Late second trimester fetal death termination with one previous cesarean section; Combination of Intra-vaginal PGE2 and PGE1 analogue: A randomized study | ||||||
| Mohamed Lotfy Mohamed El-sayed1, Mostafa Abdo Ahmed2, Ibrahim Abdel Gafor1, Mohamed El bakery Lashin2 | ||||||
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1Associate Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University 2Lecturer of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University | ||||||
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| El-sayed MLM, Ahmed M, Gafor IA, Lashin ME. Late second trimester fetal death termination with one previous cesarean section; Combination of Intra-vaginal PGE2 and PGE1 analogue: A randomized study. Edorium J Gynecol Obstet 2018;4:100019G06ME2018. |
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ABSTRACT
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Aims: The aim of this works to evaluate the effect of combining dinoprostone and misoprostol as a method of medical termination of pregnancy in patients with late 2nd trimester IUFD. Methods: This is a randomized clinical trial. 150 participants with past history of one transverse LSCS and late 2nd trimester IUFD were admitted for medical termination of pregnancy.They were divided into 3 groups, the first one received intra-vaginal misoprostol 50 μgm (4 doses with 6 hours interval), the second one received intra-vaginal dinoprostone 3 mg (4 doses with 6 hours interval) and the third one received a combination of both drugs intra-vaginally (2 doses of dinoprostone 3 mg followed by 2 doses of misoprostol 50μgm with 6 hours interval) and the clinical response to the three regimens was evaluated. Results: Dinoprostone followed by misoprostol showed statistically significant difference when compared to misoprostol and dinoprostone as regard response to induction, induction-contraction interval, induction-expulsion interval and the final outcome of termination of pregnancy. Conclusion: Using dinoprostone followed by misoprostol is more effective than using any of the two drugs separately as a method of pregnancy termination in patients with late 2nd trimester IUFD and past history of one LSCS. Keywords: Dinoprostone, Misoprostol, Second trimester termination of pregnancy, Uterine scar |
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Author Contributions
Mohamed Lotfy Mohamed El-sayed – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Mostafa Abdo Ahmed – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Ibrahim Abdel Gafor – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Mohamed El bakery Lashin – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of Submission
The corresponding author is the guarantor of submission. |
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Source of Support
None |
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Consent Statement
Written informed consent was obtained from the patient for publication of this study. |
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Conflict of Interest
Author declares no conflict of interest. |
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Copyright
© 2018 Mohamed Lotfy Mohamed El-sayed et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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